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Hurt Group - GrouplearderAcademic Training and Positions

  • 1974 - 1979 Student of biology and chemistry at the University of Regensburg
  • 1980 - 1983 PhD studies at the University of Regensburg
  • 1984 - 1986 Postdoc at the Biocenter, University of Basel, Switzerland
  • 1987 - 1994 Group Leader at the EMBL Heidelberg in the Cell Biology Program
  • since   1995 Full Professor (C4) at Heidelberg University
  • 2003 - 2005 Director of the Heidelberg University Biochemistry Center (BZH)
Groupleader Prof. Dr. Ed C. Hurt
Hurt Group - GrouplearderPrizes, Awards & Academy memberships

  • 2017 ERC Advanced Grant (read more ...)
  • 2015 Eduard Buchner Prize (read more ...)
  • 2007 Feldberg Prize (read more ...)
  • 2001 Gottfried Wilhelm Leibniz Prize
    (read more ...)
  • 1984 Kulturpreis Ostbayern (PhD award)
  • 2007 member of ACADEMIA EUROPAEA
  • 2003 member of LEOPOLDINA
  • 1994 member of EMBO

International recognition

For Publication ranking see (laborjournal.de)

Scopus citation overview: since 1997 a total of 97 cited publications with a total of 4579 citations

Hurt Group - Grouplearder10-Year-Track-Record  (Top Publications)

Markus Kornprobst, Martin Turk, Nikola Kellner, Jing-Dong Cheng, Dirk Flemming, Martin Koš, Isabelle Koš, Matthias Thoms, Otto Berninghausen, Roland Beckmann and Ed Hurt: Architecture of the 90S pre-ribosome: a structural view on the birth of the eukaryotic ribosome.
.Cell 166, 380-393 (2016).

Matthias Thoms, Emma Thomson Jochen Baßler, Marén Gnædig, Sabine Griesel and Ed Hurt: The exosome is recruited to RNA substrates through specific adapter proteins.
.Cell 162, 1029-1038 (2015).

Monika Gaik, Dirk Flemming, Alexander von Appen, Panagiotis Kastritis, Philipp Stelter, Khanh Huy Bui, Alessandro Ori, Jochen Bassler, Jessica Fischer, Elisar Barbar, Martin Beck and Ed Hurt: Structural basis for assembly and function Nup82 complex in the nuclear pore scaffold
.J. Cell Biol. 208, 283-297 doi/10.1083/jcb.201411003 (2015).

Yoshitaka Matsuo, Sander Granneman, Matthias Thoms, Rizos-Georgios Manikas, David Tollervey and Ed Hurt: Coupled GTPase and remodeling ATPase activities form a checkpoint for ribosome export.
.Nature 505, 112-116 (2014).

Jochen Baßler, Helge Paternoga, Iris Holdermann, Matthias Thoms, Sander Granneman,Clara Barrio Garcia, Afua Nyarko, Gunther Stier, Sarah A. Clark, Daniel Schraivogel, Martina Kallas, Roland Beckmann, David Tollervey, Elisar Barbar,Irmi Sinning and Ed Hurt: A network of assembly factors involved is involved in remodeling rRNA elements during pre-ribosome maturation
.J. Cell Biol. 207, 481-98. doi: 10.1083/jcb.201408111 (2014).

Dieter Kressler, Gert Bange, Yutaka Ogawa, Dagmar Pratte, Bettina Bradatsch, Daniela Roser, Jun Katahira, Irmgard Sinning, and Ed Hurt: Coordinated nuclear transport and assembly of functionally related ribosomal proteins onto nascent ribosomes by a common import adaptor.
.J. Science 338, 666-671 (2012).

Stefan Amlacher, Phillip Sarges, Dirk Flemming, Vera van Noort, Ruth Kunze, Damien Devos, Manimozhiyan Arumugam, Peer Bork and Ed Hurt: Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.
. Cell 146, 277-289 (2011).


Fields of research interest and reviewer activities

Nuclear pore complex, nucleocytoplasmic transport, transcription-coupled mRNA export, ribosome biogenesis and export nuclear envelope organization, nucleolus, sumoylation, ubiquination, transcription, chromatin organization/modification, membrane biogenesis. Over the past 10 years I served as reviewer for a number of life science journals including Nature, Science, Cell, Mol. Cell, Nature Cell Biol., J. Cell Biol., Genes Dev., EMBO J., MBC and MCB.

Press releases
Reinhart-Koselleck-Projekt für Heidelberger Biochemiker Ed Hurt (read more ... )



Alwin Kœhler, Eric Zimmermann, Maren Schneider, Ed Hurt* and Ning Zheng (senior corresponding author regarding Alwin Kœhler): Structural basis for assembly and activation of the heterotetrameric SAGA histone H2B deubiquitinase module.
.Nature Cell 141, 606-617 (2010).

Cornelia Ulbrich, Meikel Diepholz, Jochen Baßler, Dieter Kressler, Brigitte Pertschy, Kiki Galani, Bettina Bœttcher and Ed Hurt: Mechanochemical Removal of Ribosome Biogenesis Factors from Nascent 60S Ribosomal Subunits.
.Cell 138, 911-922 (2009).

Alwin Kœhler, Maren Schneider, Ghislain Cabal, Ulf Nehrbass and Ed Hurt: An integrative role of Sgf73 in multiple steps of SAGA-dependent gene gating.
.Nat.Cell Biol. 10, 707-15 (2008).

Ghislain G. Cabal, Auguste Genovesio, Susana Rodriguez-Navarro, Christophe Zimmer, Olivier Gadal, Annick Lesne, Henri Buc, Frank Feuerbach-Fournier, Jean-Christophe Olivo-Marin, Ed Hurt* and Ulf Nehrbass* (*corresponding authors): Molecular Analysis of SAGA Mediated Gene Gating In Yeast.
.Nature 441, 770-773 (2006).

Thorsten Schæfer, Bohumil Maco, Elisabeth Petfalski, David Tollervey, Bettina Boettcher, Ueli Aebi and Ed Hurt: A round of phosphorylation/de-phosphorylation triggers maturation of the pre-ribosomal 40S subunit. Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery
.Nature 441, 651-655 (2006).

Prof. Dr. Ed C. Hurt
Heidelberg University
Biochemistry Center (BZH)
Im Neuenheimer Feld 328
D-69120 Heidelberg

Phone: +49 (0)6221 544173
Fax:     +49 (0)6221 544369


Hurt Group - GrouplearderCareers of supervised graduate and postdoc students  

Yoshitaka Matsuo (former postdoc 2013)
- Assistant Professor at Tohoku University, Japan;

Dieter Kressler (former postdoc 2009)
- Professor at Université Fribourg, Switzerland;

Alwin Köhler (former postdoc 2009)
- Junior Group Leader at Max F. Perutz Laboratories,
Vienna, Austria;

Michal Skruzny (former postdoc 2008)
- Project Group Leader at Max-Planck-Institute for Terrestrial Microbiology, Marburg, Germany

Vikram Panse (former postdoc 2006)
- Principal investigator at University of Zurich, Switzerland;

Tamás Fischer (former postdoc 2006)
- Associate Professor at John Curtin School of Medicine, Australien National University Canberra/Australia ;

Tracy Nissan (former postdoc 2004)
- Junior Group Leader at Umea University, Sweden;

Susana Rodriguez-Navarro (former postdoc 2004)
- Principal investigator at CIPF, Valencia, Spain;

Katja Sträßer (former PhD student 2003)
- Principal investigator at the Justus-Liebig-University, Giessen, Germany;

Helge Großhans (former PhD student 2002)
- Group Leader at Friedrich Miescher Institute Basel, Switzerland;

Markus Kuenzler (former PhD student 2001)
- Senior Scientist at the ETH Zürich;

Symeon Siniossoglou
(former PhD student 2000)
- Principal investigator at CIMR, Cambridge, UK;

Isabelle Sagot (former postdoc 2001)
- Senior researcher at CNRS/Université Bordeaux, France;

Olivier Gadal (former postdoc 2000)
- Principal investigator at CNRS/Université Toulouse, France;


George Simos (former postdoc 1998)
- Professor at University of Thessaly, Larissa, Greece;

Buket Kosova (former PhD student 1999)
- Senior researcher at Ege University Izmir/Turkey;

Helena Santos-Rosa (former postdoc 1998)
- Research associate at University of Cambridge/The Gurdon Institute, UK;

Jun Katahira (former postdoc 1998)
- Associate Professor at University of Osaka/Japan

Stefan Hannus (former PhD student 1998)
- Intana Biosciences Martinsried

Nikolaus Schlaich (former postdoc 1997)
- Assistant Professor at RWTH Aachen, Germany;

Thierry Berges (former postdoc 1996)
- Professor at UFR Sciences, Poitiers, France;

Emmanuelle Fabre (former PhD student 1994)
- Group Leader at the Institut Universitaire d'Hématologie, Paris, France;

Ulf Nehrbass (former PhD student 1994)
- CNRS research director of the Institute Pasteur, Paris, France and Director of Pasteur Institute in Seoul, Korea;

Valérie Doye (former postdoc 1994)
- Group Leader and at the Institut Jacques Monod, Paris, France, France;

Ralf Jansen (former PhD student 1993)
- Full Professor at the Interfaculty Institute of Biochemistry (IFIB), University of Tuebingen, Germany.